O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma
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o14: cellular and molecular mechanisms of spinal cord trauma
the prevalence of spinal cord injury (sci) is about 2.5 million in the worldwide and more than 130,000 new injuries reported each year. regeneration in the cns versus the pns is very different from the other tissues and many factors can prevent regeneration in pns and specially cns. previous researches demonstrated that regeneration of cns can inhibit by inhibitory molecules and glial scar. the...
full textCellular and Molecular Mechanisms Involved in Neuroinflammation after Acute Traumatic Spinal Cord Injury
Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neut...
full textMolecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.
Following axotomy, a complex temporal and spatial coordination of molecular events enables regeneration of the peripheral nerve. In contrast, multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration in the central nervous system. In this review, we examine the current understanding of differences in protein expression and post-translational modifications...
full textMolecular and cellular development of spinal cord locomotor circuitry
The spinal cord of vertebrate animals is comprised of intrinsic circuits that are capable of sensing the environment and generating complex motor behaviors. There are two major perspectives for understanding the biology of this complicated structure. The first approaches the spinal cord from the point of view of function and is based on classic and ongoing research in electrophysiology, adult b...
full textTrauma of the spine and spinal cord.
Although CT continues to be of great importance in the evaluation of the spine after acute trauma, MRI is gaining acceptance and is considered indispensable in some situations. At our institution, in all patients who have suffered head trauma and have an immobilized cervical spine, a CT of the cervical spine is obtained at the same time as the head CT. In these patients, 3 mm thick spiral secti...
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Journal title
volume 2 issue 4
pages 14- 14
publication date 2014-12
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